23484.rar

: Protein Kinase G Iα (PKG Iα) is usually activated by cGMP, but it can also be activated by "oxidative stress" (specifically the formation of a disulfide bond at Cys42).

: Use of C57BL/6 mice and specialized Cys42Ser KI (knock-in) mice that are resistant to PKG oxidative activation. 23484.rar

: Isolation of mesenteric arteries and thoracic aorta; use of Danish Myo tension systems to measure vessel contraction/relaxation. : Protein Kinase G Iα (PKG Iα) is

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