: The standard material deposited in the European Pharmacopoeia. It consists of four crystallographically independent molecules arranged in pairs via hydrogen-bonded carboxylic dimers ( ResearchGate ).
Researchers using X-ray powder diffraction (XRPD) and thermal analysis have identified three primary forms: 54757.rar
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: This conversion occurs through moderate heating (approximately 200 °C ) under vacuum. 54757.rar
: Form I can be quantitatively converted into Form II.
: These findings suggest that the manufacturing environment (heat and solvent choice) directly determines which form of the drug is produced. 4. Conclusion