Abnormal Serum Light Chain Ratio Apr 2026

Conditions like rheumatoid arthritis or recent viral infections can temporarily increase light chain production.

Conditions like multiple myeloma or MGUS (Monoclonal Gammopathy of Undetermined Significance) can cause one type of light chain to be overproduced, skewing the ratio. Abnormal Serum Light Chain Ratio

An indicates that the balance between two types of proteins— kappa and lambda free light chains—is outside the standard range of roughly 0.26 to 1.65 . These proteins are produced by plasma cells to help your immune system fight infections. These proteins are produced by plasma cells to

Because the kidneys filter these proteins out of your blood, chronic kidney disease can lead to higher levels and slightly altered ratios. Common Causes of an Abnormal Ratio Your doctor

While an abnormal ratio can sometimes indicate a serious condition, it is often caused by non-cancerous factors. Common Causes of an Abnormal Ratio

Your doctor will likely look at your results alongside other health markers to determine if follow-up is needed: Free Light Chains: MedlinePlus Medical Test