Alkalating Agent Page

Alkylating agents are a critical class of chemotherapy drugs that act directly on the DNA of cells to prevent them from growing and dividing. Unlike many other cancer treatments, they are , meaning they can attack cancer cells at any stage of their life cycle. How They Work

: Once the DNA damage becomes too severe to repair, the cell's internal checkpoints trigger programmed cell death (apoptosis). From old alkylating agents to new minor groove binders alkalating agent

: The drug attaches an "alkyl group" to a DNA base, most frequently at the N7 position of guanine . Alkylating agents are a critical class of chemotherapy

: Bifunctional agents can link two DNA bases together (interstrand or intrastand cross-linking), which prevents the DNA strands from separating for replication. From old alkylating agents to new minor groove

: Repair enzymes in the cell may attempt to fix the damaged DNA, which often results in further strand breaks and fragmentation.