Atopy -

: Systemic immune priming eventually leads to upper and lower airway inflammation. 3. Key Management Strategies

While there is currently no cure, management focuses on controlling inflammation and restoring barrier function. Atopy - StatPearls - NCBI Bookshelf - NIH : Systemic immune priming eventually leads to upper

Atopy is a genetic predisposition toward developing exaggerated IgE-mediated immune responses to common environmental allergens. Clinically, it manifests as a triad of conditions—, allergic rhinitis (hay fever) , and allergic asthma —often appearing sequentially in a pattern known as the "atopic march". 1. Pathophysiology and Mechanism Atopy - StatPearls - NCBI Bookshelf - NIH

Atopy typically follows a predictable chronological progression: allergic rhinitis (hay fever)

: These cells produce cytokines (IL-4, IL-13) that trigger B cells to differentiate into plasma cells producing allergen-specific IgE.

: Sensitization through inflamed skin can lead to early-onset food allergies.