switches sides and helps Frank create a symptomatic treatment to temporarily stall his zombification. Frank defeats Brock in a final showdown atop a tank.
Frank eventually discovers that the mastermind behind the outbreak is . Carlito and his sister, Isabela , are survivors of a small village in Santa Cabeza that was wiped out by the U.S. military to cover up a failed livestock experiment. The experiment involved genetically engineered wasps that accidentally turned the village's population into zombies.
In the canon conclusion, the U.S. military—led by —arrives not to rescue people, but to eliminate all witnesses of the outbreak.
The game ends with Frank and Isabela surrounded by zombies, with Frank letting out a desperate scream into the sky.
Once inside, Frank finds a group of survivors in the mall's Entrance Plaza, but a panicked woman inadvertently lets the zombie horde into the building. Frank escapes to a secure room where he meets:
The epilogue reveals that Frank managed to escape Willamette and publish his report, forcing the government to admit partial responsibility, though they successfully blamed the incident on terrorists rather than their own failed experiments.