Measuring aspirin resistance is complex because there is no "gold standard" test that perfectly correlates with clinical outcomes.

Resistance to aspirin, often referred to as "aspirin failure" or "biochemical aspirin resistance," is a critical topic in cardiovascular medicine. It refers to the inability of aspirin to reduce platelet production of thromboxane A2, leaving patients at a higher risk for thrombotic events despite therapy.

Platelets can be activated via pathways not targeted by aspirin (e.g., ADP, thrombin, or collagen).

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The presence of aspirin resistance has significant "real-world" consequences for patient safety.