Somatic mutations in AKT, particularly the , alter the PH domain structure, leading to constitutive membrane localization and hyperactivation of downstream effectors like mTOR and ERK1/2. This promotes uncontrolled proliferation and resistance to apoptosis. AKT1 Transcriptomic Landscape in Breast Cancer Cells - MDPI
: Central to cell survival and general growth; its depletion leads to significant transcriptomic shifts in breast cancer cells. File: AKT_collection_compressed_2022-11-20.zip ...
Research indicates that AKT isoforms are not functionally redundant: Somatic mutations in AKT, particularly the , alter
: The primary regulator of insulin-dependent glucose uptake in muscle and adipose tissue. Somatic mutations in AKT
Multi-Isoform AKT Signaling: A Systems-Level Analysis of Cellular Homeostasis and Oncogenesis