The Shandia are suffering from a deadly "Tree Fever" epidemic that is decimating their population. Noland intervenes just as a girl named Mousse is about to be sacrificed to a giant snake they worship as a god.

Despite his initial hatred, Kalgara begins to see the logic in Noland’s "progress" after his own daughter, Seto, is cured. Why It Matters

While the present-day battle against Enel reaches its fever pitch, the story takes a dramatic turn 400 years into the past. We see the legendary explorer Mont Blanc Noland—not as the "liar" from storybooks, but as a courageous and highly skilled botanist.