To play a Rango ISO on original hardware (typically a modded Xbox 360 or PS3), you usually follow these steps:
Use a tool like Xbox Image Browser to extract the game files from the ISO. Rango [Region Free][ISO]
If a game is not region free but you have a modded console, tools like XEXTool can sometimes be used to manually remove region restrictions from the default.xex file. To play a Rango ISO on original hardware
An ISO file is a complete "disc image" of the game's original DVD. It is typically used for preservation, emulation, or playing via hard drive on modified hardware. Rango [Region Free][ISO]