The story begins with Sherlock Holmes (Benedict Cumberbatch) waiting for Jim Moriarty’s posthumous move while solving a string of minor crimes. The main case appears when a young man is found dead in a car, leading Sherlock to investigate the mysterious destruction of six identical plaster busts of Margaret Thatcher.

The episode is noted for its sharp divide between the first half’s traditional detective fun and the second half’s heavy emotional stakes.

While highly anticipated, "The Six Thatchers" received a mixed response from fans and critics, often cited as one of the show's lower-rated episodes compared to earlier seasons.