[s5e22] What A Difference - A Day Makes

In , the Season 5, Episode 22 milestone titled " What a Difference a Day Makes " is a landmark 100th episode that originally aired on May 7, 2009. It is widely celebrated for its emotional depth, shifting from a planned grand wedding for Meredith and Derek to a poignant ceremony for Izzie Stevens and Alex Karev. The Unexpected Wedding

While the wedding takes center stage, the hospital remains in chaos due to a tragic car crash involving college students on their way to graduation. [S5E22] What a Difference a Day Makes

: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances. In , the Season 5, Episode 22 milestone

: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts : Creator Shonda Rhimes noted that Denny's appearance

: Alex delivers a powerful, spontaneous speech adapted from a valedictorian's graduation address, promising to be accountable to Izzie through any future challenges. Medical Drama and Character Growth

: To promote the 100th episode, ABC created a real wedding website for Meredith and Derek that fans could actually visit and RSVP to.