Go to Top

phosphorylates Serine 422 at the C-terminal hydrophobic motif.

: Gene variants conferring increased SGK1 activity are associated with salt-sensitive hypertension and obesity.

: The human SGK1 protein is a serine/threonine-protein kinase consisting of 431 amino acids with a molecular mass of approximately 49 kDa . It features an N-terminal PX-like (phox homology) domain, a central catalytic kinase domain, and a C-terminal hydrophobic motif.